Robert W. Shafer
Publication Details
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Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection.
AIDS. 2010; (12): 1867-76
To inform guidelines concerning when to initiate combination antiretroviral therapy (ART), we investigated whether CD4(+) T-cell counts (CD4 cell counts) continue to increase over long periods of time on ART. Losses-to-follow-up and some patients discontinuing ART at higher CD4 cell counts hamper such evaluation, but novel statistical methods can help address these issues. We estimated the long-term CD4 cell count trajectory accounting for losses-to-follow-up and treatment discontinuations.
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