Richard Tsien
Publication Details
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Structural basis of ion channel permeation and selectivity.
Curr Opin Neurobiol. 1994; (3): 313-23
There has been rapid progress in understanding the structural basis of ion selectivity and permeation in both ligand- and voltage-gated channels. Recognition of similarities in overall architecture within a channel class has led to an increasing focus on the specific molecular determinants that endow a channel with its own distinctive character. It has been possible in some cases to identify individual amino acids essential for ion selectivity.
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