Steven Foung
Publication Details
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Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptide.
Bioorg Med Chem Lett. 2004; (17): 4529-32
A panel of human monoclonal and recombinant antibody light chains was screened for cleavage of the synthetic peptide corresponding to a neutralizing epitope of hepatitis C virus (residues 192-205 of envelope glycoprotein E1). One of the 39 light chains studied hydrolyzed the Val197-Ser198 bond of the peptide with Km and kcat values of 223 +/- 7 microM and 0.087 +/- 0.001 min(-1).
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