David A. Spain, MD
Publication Details
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Lazaroid improves intestinal blood flow in the rat during hyperdynamic bacteraemia.
Br J Surg. 1997; (12): 1717-21
Intestinal mucosal hypoperfusion and loss of barrier function during sepsis may contribute to maintaining the septic state. Free radicals are produced during sepsis and antioxidants improve survival from experimental sepsis. It is unclear whether endothelial cell injury from free radicals results in altered microvascular reactivity. Lazaroids are antioxidants which scavenge radicals and block lipid radical chain reactions. The authors sought to determine whether lazaroids altered the intestinal microvascular responses to sepsis.
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