David A. Relman
Publication Details
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Diagnosis and monitoring of Whipple disease by polymerase chain reaction.
Ann Intern Med. 1997; (7): 520-7
Whipple disease is a chronic, multisystem disorder associated with infection with Tropheryma whippelii, an organism that has not yet been grown on artificial media. In some cases, the diagnosis of Whipple disease is uncertain if it is based on histology alone. Although antibiotic regimens of various durations have been used, the disease recurs in about one third of cases. No test for cure is available.
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