Alan F. Schatzberg
Publication Details
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A pilot study of the phase angle between cortisol and melatonin in major depression - a potential biomarker?
J Psychiatr Res. 2010; (2): 69-74
Hypothalamic-pituitary-adrenal (HPA) axis and melatonin rhythm alterations have been independently reported in major depression (MDD) as well as in insomnia. In this pilot study, we link cortisol and melatonin rhythms and propose that the phase angle between cortisol acrophase (CA) and dim-light melatonin onset (20 pg/ml) (DLMO-20) may yield a useful state specific biomarker for MDD.
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