Rajesh Dash, MD, PhD
Publication Details
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Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
Circulation. 2001; (6): 889-96
Relieving the inhibition of sarcoplasmic reticular function by phospholamban is a major target of beta-adrenergic stimulation. Chronic beta-adrenergic receptor activity has been suggested to be detrimental, on the basis of transgenic overexpression of the receptor or its signaling effectors. However, it is not known whether physiological levels of sympathetic tone, in the absence of preexisting heart failure, are similarly detrimental.
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