Lawrence Tim Goodnough
Publication Details
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Iron overload and toxicity: the hidden risk of multiple blood transfusions.
Vox Sang. 2009; (3): 185-97
The quantity of iron in body is carefully regulated, primarily by control of iron absorption, and excess total body iron can be extremely toxic. Since humans have no mechanism for elimination of excess iron, multiple transfusions of red blood cells, which are required for the management of a number of disorders, inevitably result in iron overload. Cumulative iron overload, in turn, leads to iron toxicity with organ dysfunction and damage.
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