Timothy Angelotti MD, PhD
Publication Details
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Molecular insights into alpha2 adrenergic receptor function: Clinical implications
Seminars in Anesthesia, Perioperative Medicine and Pain. 2007; (1): 28-34
Efferent signaling from the sympathetic nervous system integrates myriad vital functions. Modulation of sympathetic neuron signaling occurs in part by feedback inhibition of neurotransmitter release, mediated largely via alpha2a and/or 2c adrenergic receptors alpha2a&c ARs). This review will describe an overview of our current understanding of alpha2a&c AR biology, clinical implications of these findings, and the possible clinical importance of genetic variants of alpha2a&c ARs.
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