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Linda Yip

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Publication Details

  • Hypertonic saline resuscitation: efficacy may require early treatment in severely injured patients.

    Hashiguchi N, Lum L, Romeril E, Chen Y, Yip L, Hoyt DB, Junger WG. J Trauma. 2007; 62 (2): 299-306

    Activation of polymorphonuclear neutrophils (PMN) is a critical event leading to host tissue injury and organ damage after trauma. Hypertonic saline (HS) resuscitation prevents PMN activation in vitro and in animal models. Here, we studied how clinical parameters and timing requirements influence the efficacy of HS in suppressing PMN activation.

    PubMedID: 17297316

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