Francis Blankenberg
Publication Details
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Zinc chloride-mediated reduction of apoptosis as an adjunct immunosuppressive modality in cardiac transplantation.
J Heart Lung Transplant. 2002; (3): 360-5
Zinc (Zn) blocks caspase-3 activation in cardiac allografts and therefore may synergistically decrease apoptosis along with cyclosporine (CsA), which inhibits mitochondrial release of cytochrome c. Simultaneous treatment of rat recipients of heterotopic heart transplants with zinc chloride (ZnCl(2)) thus may allow lower doses of CsA for immunosuppression.
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