Richard A. Jaffe
Publication Details
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Pregnancy does not increase susceptibility to bupivacaine in spinal root axons.
Anesthesiology. 1997; (3): 610-6
The underlying mechanism of enhanced antinociceptive effects and increased susceptibility to local anesthetics during pregnancy is not known. Mechanical, hormonal, biochemical, and neural changes have been suggested. The authors measured the susceptibility of individual spinal root axons to bupivacaine during late pregnancy in rats and compared them with similar measurements in nonpregnant rats.
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