Greer Murphy M.D., Ph.D.
Publication Details
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Pharmacogenetics of antidepressant medication intolerance.
Am J Psychiatry. 2003; (10): 1830-5
The authors sought to identify genetic markers for antidepressant medication intolerance. Genetic variation in drug metabolizing enzymes such as cytochrome P450 2D6 (CYP2D6) has been postulated to underlie antidepressant intolerance (pharmacokinetic effect). However, variation in genes encoding serotonin receptors could also explain antidepressant side effects (pharmacodynamic effect).
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