Jianghong Rao
Publication Details
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Cell-permeable near-infrared fluorogenic substrates for imaging beta-lactamase activity.
J Am Chem Soc. 2005; (12): 4158-9
This communication describes a design of cell-permeable near-infrared fluorogenic substrates for imaging beta-lactamase expression in living mammalian cells. This design is based on fluorescence energy transfer resonance and utilizes a peracetylated d-glucosamine to facilitate the transport of the near-infrared probe across cell membranes. This new type of fluorogenic probe may also be applied to image gene expression in living animals.
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