William Talbot

Putting the glue in glia: Necls mediate Schwann cell axon adhesion.
Perlin JR, Talbot WS. J Cell Biol. 2007; 178 (5): 721-3
Interactions between Schwann cells and axons are critical for the development and function of myelinated axons. Two recent studies (see Maurel et al. on p. 861 of this issue; Spiegel et al., 2007) report that the nectin-like (Necl) proteins Necl-1 and -4 are internodal adhesion molecules that are critical for myelination. These studies suggest that Necl proteins mediate a specific interaction between Schwann cells and axons that allows proper communication of the signals that trigger myelination.

PubMedID: 17724116