Community Academic Profiles

John Gosling

Publication Details

  • Correlation between the structure and function of the rabbit urinary bladder following partial outlet obstruction.

    Gosling JA, Kung LS, Dixon JS, Horan P, Whitbeck C, Levin RM. J Urol. 2000; 163 (4): 1349-56

    To understand the relationship between contractile and structural changes in the obstructed bladder, rabbit bladder was partially obstructed for up to 70 days and alterations in tension response to field stimulation and carbachol were compared with alterations in ultrastructure and innervation of detrusor smooth muscle (SM). The effect of partial outlet obstruction on the physiological responses to field stimulation (FS) (nerve mediated contraction) and carbachol (receptor mediated contraction) were correlated with the structure and innervation of the detrusor smooth muscle (SM) of the same animal during a 70 day period.

    PubMedID: 10737542

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