Daniel Herschlag
Publication Details
-
Catalytic promiscuity and the evolution of new enzymatic activities.
Chem Biol. 1999; (4): R91-R105
Several contemporary enzymes catalyze alternative reactions distinct from their normal biological reactions. In some cases the alternative reaction is similar to a reaction that is efficiently catalyzed by an evolutionary related enzyme. Alternative activities could have played an important role in the diversification of enzymes by providing a duplicated gene a head start towards being captured by adaptive evolution.
Help