Yueh-hsiu Chien
Publication Details
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Thymic maturation determines gammadelta T cell function, but not their antigen specificities.
Curr Opin Immunol. 2009; (2): 140-5
gammadelta T cells contribute uniquely to host immune defense, but how they do so remains unclear. Recent work suggests that thymic selection does little to constrain gammadelta T cell antigen specificities, but instead determines their effector fate. When triggered through the T cell receptor, ligand-experienced cells make IFNgamma, whereas ligand-naïve gammadelta T cells produce IL-17, a major initiator of inflammation. These advances warrant a fresh look at how gammadelta T cells may function in the immune system.
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