Thomas Quertermous, MD
Publication Details
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Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery.
Anat Rec A Discov Mol Cell Evol Biol. 2005; (2): 1165-75
In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular morphogenesis. In the wild-type mouse, mesenteric vessels are shaped like rakes consisting of a long stalk and short branches at the periphery. In contrast, those in transgenic mice showed typical dendritic architecture consisting of a few large primary branches with smaller spreading branches. The phenotype of mice overexpressing Del1 suggests the existence of a tissue-specific mechanism for branching morphogenesis in the mesentery.
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