Jian Luo
Publication Details
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Acrolein inflicts axonal membrane disruption and conduction loss in isolated guinea-pig spinal cord.
Neuroscience. 2002; (2): 337-40
We have examined the effect of acrolein, an aldehyde product of lipid peroxidation, on axons in isolated guinea-pig spinal cord white matter. We found that 200 microM acrolein, but not 50 microM, induced a time-dependent loss of compound action potential conduction. Such conduction loss was irreversible within 1 h after acrolein perfusion. Parallel anatomical assessment indicates membrane integrity breakdown based on a horseradish peroxidase-exclusion assay. This is the first report to suggest that acrolein inflicts severe axonal damage. Since axonal damage within white matter plays a key role in the pathology of traumatic spinal cord injury, we suggest that acrolein may be a critical factor in mediating secondary functional loss.
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