Michael F. Clarke, M.D.
Publication Details
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Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.
Science. 1984; (4662): 636-9
The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.
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