Douglas Vollrath
Publication Details
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Mertk drives myosin II redistribution during retinal pigment epithelial phagocytosis.
Invest Ophthalmol Vis Sci. 2009; (5): 2427-35
Mertk is a key phagocytic receptor in the immune, male reproductive, and visual systems. In the retinal pigment epithelium, Mertk is required for the daily ingestion of photoreceptor outer segment (OS) tips. Loss of Mertk function causes retinal degeneration in rats, mice, and humans; however, little is known about the mechanism by which Mertk regulates the ingestion phase of retinal pigment epithelial (RPE) phagocytosis. To address this, the authors sought proteins that associated with Mertk during OS phagocytosis.
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