Laura C. Lazzeroni, Ph.D.
Publication Details
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Multipoint mapping calculations for sperm-typing data.
Am J Hum Genet. 1994; (3): 431-6
This paper explains how multipoint likelihoods can be computed for sperm-typing data. Experimental errors such as multiple sperm per tube, inadequate amplification, and contamination by exogenous DNA are explicitly taken into account. By limiting the number of sperm theoretically possible per tube to a predetermined maximum and by assuming no chiasma interference, maximum-likelihood estimation can be carried out rapidly using the theory of hidden Markov chains.
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