Jill Helms
Publication Details
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Wnt signaling promotes Müller cell proliferation and survival after injury.
Invest Ophthalmol Vis Sci. 2013; (1): 444-53
Müller glia respond to retinal injury by a reactive gliosis, but only rarely do mammalian glial cells re-enter the cell cycle and generate new neurons. In the nonmammalian retina, however, Müller glia act as stem/progenitor cells. Here, we tested the function of Wnt signaling in the postinjury retina, focusing on its ability to influence mammalian Müller cell dedifferentiation, proliferation, and neurogenesis.
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