John Cooke, MD, PhD
Publication Details
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Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance.
Cardiovasc Diabetol. 2011: 68
High fat diet impairs nitric oxide (NO) bioavailability, and induces insulin resistance. The link between NO availability and the metabolic adaptation to a high fat diet is not well characterized. The purpose of this study was to investigate the effect of high fat diet on metabolism in mice with decreased (eNOS-/-) and increased (DDAH overexpressed) NO bioavailability.
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