Gusti Zeiner

SmD1 is required for spliced leader RNA biogenesis.
Zeiner GM, Foldynová S, Sturm NR, Lukes J, Campbell DA. Eukaryot Cell. 2004; 3 (1): 241-4
The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans-splicing competence. In Trypanosoma brucei, RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3'-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U28 pseudouridylation was unaffected.

PubMedID: 14871954