Michele Calos
Publication Details
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Safe genetic modification of cardiac stem cells using a site-specific integration technique.
Circulation. 2012; (11 Suppl 1): S20-8
Human cardiac progenitor cells (hCPCs) are a promising cell source for regenerative repair after myocardial infarction. Exploitation of their full therapeutic potential may require stable genetic modification of the cells ex vivo. Safe genetic engineering of stem cells, using facile methods for site-specific integration of transgenes into known genomic contexts, would significantly enhance the overall safety and efficacy of cellular therapy in a variety of clinical contexts.
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