Jon Park, M.D., FRCSC
Publication Details
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The design of a heterocellular 3D architecture and its application to monitoring the behavior of cancer cells in response to the spatial distribution of endothelial cells.
Adv Mater. 2012; (39): 5339-44
The spatial cell distribution is one of the critical features for governing cellular interactions and their consequent behaviors. Here we suggest a novel method of building a hierarchical cellular structure by stacking cell-attached microplate structures with specific configurations within hydrogel layers. This method is applied to the reconstruction of the 3D architecture of a liver lobule and the development of an experimental model of the various phases of cancer angiogenesis.
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