Roham Zamanian
Publication Details
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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension.
Arterioscler Thromb Vasc Biol. 2011; (4): 814-20
The G-protein-coupled receptor APJ and its ligand apelin are highly expressed in the pulmonary vasculature, but their function in this vascular bed is unclear. We hypothesized that disruption of apelin signaling would lead to worsening of the vascular remodeling associated with pulmonary hypertension (PH).
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