Robert W. Shafer
Publication Details
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Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy.
AIDS. 2006; (11): 1503-13
Peripheral neuropathy (PN) often complicates nucleoside reverse transcriptase inhibitor (NRTI) therapy of HIV infection and may involve mitochondrial dysfunction. Since iron deficiency is associated with some types of PN, and iron is essential for mitochondrial function, we tested the hypothesis that hemochromatosis (HFE) gene mutations influence susceptibility to NRTI-induced PN.
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