Peter Parham
Publication Details
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Stress management: MHC class I and class I-like molecules as reporters of cellular stress.
Immunity. 2003; (4): 469-77
The evolutionarily ancient intracellular stress response protects cells from the effects of external and internal forces which perturb cellular metabolism. Members of the major histocompatibility complex (MHC) class I-like superfamily act as cell surface indicators of the intracellular stress response. Cellular immunity employs these indicators as a cue for elimination of damaged, infected, and malignant cells, promoting the health of the individual and the evolutionary success of the species.
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