Mary Polan
Publication Details
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Menstrual phase-dependent gene expression differences in periurethral vaginal tissue from women with stress incontinence.
Am J Obstet Gynecol. 2003; (1): 89-97
The mechanical stability of the genitourinary tract is dependent on intact collagen fibers that support the bladder neck, urethra, and pelvic organs. We hypothesize that genetic differences in collagen metabolism may contribute to stress urinary incontinence. Because sex hormones have substantial influence on the female lower urinary tract throughout adult life, we investigated the gene expression of vaginal tissue of women with stress incontinence compared with women with no stress incontinence in the proliferative phase of the menstrual cycle.
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