David Fiorentino, MD, PhD
Publication Details
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The direct cellular target of topically applied pimecrolimus may not be infiltrating lymphocytes.
Br J Dermatol. 2011; (5): 996-1003
Topically applied calcineurin inhibitors have been shown to be effective in the treatment of atopic dermatitis. When systemically administered, these agents cause immunosuppression via inhibition of calcineurin in lymphocytes. As topical agents, the mechanism of action is poorly defined.
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