H. Peter Lorenz, MD
Publication Details
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Fetal and adult fibroblasts have similar TGF-beta-mediated, Smad-dependent signaling pathways.
Plast Reconstr Surg. 2006; (7): 2277-83
The scarless fetal skin-healing mechanism is mediated in part by the fibroblast and involves differential expression of transforming growth factor (TGF)-beta isoforms 1 and 3. The authors hypothesized that fetal and adult fibroblasts respond differently to TGF-beta isoform-specific stimulation, which may influence whether wounds scar. Connective tissue growth factor (CTGF), Smad3, and Smad7 are TGF-beta target genes. Expression of these targets was quantitated after TGF-beta1 and -beta3 stimulation of fetal and adult fibroblasts.
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