John Cooke, MD, PhD
Publication Details
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Nitric oxide regulates monocyte chemotactic protein-1.
Circulation. 1997; (3): 934-40
Monocyte chemotactic protein-1 (MCP-1) is a 76-amino-acid chemokine thought to be the major chemotactic factor for monocytes. We and others have demonstrated that NO inhibits monocyte-endothelial cell interactions and atherogenesis. We hypothesize that the antiatherogenic effect of NO may be due in part to its inhibition of MCP-1 expression.
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