KC Huang
Publication Details
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Posttranslational acetylation of α-tubulin constrains protofilament number in native microtubules.
Curr Biol. 2012; (12): 1066-74
Microtubules are built from linear polymers of α-β tubulin dimers (protofilaments) that form a tubular quinary structure. Microtubules assembled from purified tubulin in vitro contain between 10 and 16 protofilaments; however, such structural polymorphisms are not found in cells. This discrepancy implies that factors other than tubulin constrain microtubule protofilament number, but the nature of these constraints is unknown.
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