Richard B. Moss
Publication Details
-
Sputum tobramycin concentrations in cystic fibrosis patients with repeated administration of inhaled tobramycin.
J Aerosol Med Pulm Drug Deliv. 2013; (2): 69-75
Dosing of tobramycin solution for inhalation (TSI) in cystic fibrosis (CF) patients was based on single-dose pharmacokinetic studies. This investigation was prompted by evidence of possible antibiotic accumulation in respiratory secretions with repeated dosing. The objectives were to evaluate whether tobramycin accumulates in respiratory secretions with repeated inhalation, compare total and biologically active tobramycin concentrations in CF sputum, and evaluate sputum induction for obtaining secretions for drug concentration assay.
Help