Leonore A. Herzenberg
Publication Details
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Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice.
PLoS One. 2012; (4): e35733
Celastrol, an active compound extracted from the root of the Chinese medicine "Thunder of God Vine" (Tripterygium wilfordii), exhibits anticancer, antioxidant and anti-inflammatory activities, and interest in the therapeutic potential of celastrol is increasing. However, described side effects following treatment are significant and require investigation prior to initiating clinical trials. Here, we investigated the effects of celastrol on the adult murine hematopoietic system.
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