Frederic Menard
Publication Details
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Rh(I)-catalyzed carbonylative ring opening of diazabicycles with acyl anion equivalents.
Org Lett. 2007; (26): 5365-7
A catalytic desymmetrization of strained alkenes by ring-opening of meso-diazabicycles with acyl anion nucleophiles is reported. Densely functionalized trans-1,2-hydrazinoacyl cyclopentene building blocks are obtained stereoselectively. The acyl anion equivalent is generated in situ under very mild conditions from readily available organoboron precursors.
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