Jorg Goronzy
Publication Details
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T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis.
Arthritis Rheum. 2005; (5): 1392-401
Patients with rheumatoid arthritis (RA) accumulate prematurely aged T cells that have acquired a new profile of regulatory receptors. Many of the de novo-expressed receptors are typically found on natural killer cells, including CX(3)CR1, the receptor for the chemokine fractalkine (FKN). This study explored whether interactions between CX(3)CR1 and FKN are relevant for T cell functions in rheumatoid synovitis.
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