Karl Sylvester
Publication Details
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Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cells.
J Pediatr Surg. 2006; (4): 624-32; discussion 624-32
Osteosarcoma arises predominantly in the metaphyseal growth plate of children during the growth spurt years. These tumors develop during physiological growth from an expanding cell population, suggesting that the transformed cell is a bone-forming progenitor. An absence of the p53 oncogene has been implicated in the origin and progression of osteosarcoma, and because mesenchymal stem cells (MSCs) are the physiological osteogenic progenitor cell population, we hypothesized that a p53-/- mutation would enhance bone differentiation of MSC in a mouse model of in vitro osteogenesis.
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