Yoon-Jae Cho
Publication Details
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Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients.
Clin Cancer Res. 2011; (21): 6791-801
The transcription factor Forkhead box M1 (FoxM1) is a key regulator of cell-cycle progression. It is involved in the development of multiple organs, and we have previously reported on its important role for the mitotic entry of cerebellar granule neuron precursors. Constitutive expression of FoxM1 is required for the growth of multiple cancer types. This study aimed to determine its role in medulloblastoma, the most frequent malignant brain tumor in childhood that can derive from cerebellar granule neuron precursors.
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