Eswar Krishnan, MD M.Phil
Publication Details
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Improved responsiveness and reduced sample size requirements of PROMIS physical function scales with item response theory.
Arthritis Res Ther. 2011; (5): R147
The Health Assessment Questionnaire Disability Index (HAQ) and the SF-36 PF-10, among other instruments, yield sensitive and valid Disability (Physical Function) endpoints. Modern techniques, such as Item Response Theory (IRT), now enable development of more precise instruments using improved items. The NIH Patient Reported Outcomes Measurement Information System (PROMIS) is charged with developing improved IRT-based tools. We compared the ability to detect change in physical function using original (Legacy) instruments with Item-Improved and PROMIS IRT-based instruments.
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