Mary Frances Nunez Teruel
Publication Details
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Control of astrocyte Ca(2+) oscillations and waves by oscillating translocation and activation of protein kinase C.
Curr Biol. 2001; (14): 1089-97
Glutamate-induced Ca2+ oscillations and waves coordinate astrocyte signaling responses, which in turn regulate neuronal excitability. Recent studies have suggested that the generation of these Ca2+ oscillations requires a negative feedback that involves the activation of conventional protein kinase C (cPKC). Here, we use total internal reflection fluorescence (TIRF) microscopy to investigate if and how periodic plasma membrane translocation of cPKC is used to generate Ca2+ oscillations and waves.
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