Ash A. Alizadeh, MD/PhD
Publication Details
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Surprise! HSC are aberrant in chronic lymphocytic leukemia.
Cancer Cell. 2011; (2): 135-6
In this issue of Cancer Cell, Kikushige et al. report the surprising finding that, in human chronic lymphocytic leukemia (CLL), hematopoietic stem cells (HSC) aberrantly generate clonal B cells with CLL-like phenotypes, which implicate HSC in the pathogenesis of this mature lymphoid malignancy and has major implications for CLL therapies.
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