John Cooke, MD, PhD
Publication Details
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Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity.
Arterioscler Thromb Vasc Biol. 2008; (4): 692-7
Previous studies suggest that nitric oxide (NO) may modulate insulin-induced uptake of glucose in insulin-sensitive tissues. Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase (NOS). We hypothesized that a reduction in endogenous ADMA would increase NO synthesis and thereby enhance insulin sensitivity.
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