Publications
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Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion.
Zhou P,
Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T, Südhof TC.
EMBO J.
2013;
32
(1):
159-71
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A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.
Araç D,
Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT.
EMBO J.
2012;
31
(6):
1364-78
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C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis.
Kaeser-Woo YJ,
Yang X, Südhof TC.
J Neurosci.
2012;
32
(8):
2877-85
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CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
Sharma M,
Burré J, Bronk P, Zhang Y, Xu W, Südhof TC.
EMBO J.
2012;
31
(4):
829-41
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Calcium control of neurotransmitter release.
Südhof TC,
Cold Spring Harb Perspect Biol.
2012;
4
(1):
a011353
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Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development.
Anderson GR,
Galfin T, Xu W, Aoto J, Malenka RC, Südhof TC.
Proc Natl Acad Sci U S A.
2012;
109
(44):
18120-5
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Comprehensive qPCR profiling of gene expression in single neuronal cells.
Citri A,
Pang ZP, Südhof TC, Wernig M, Malenka RC.
Nat Protoc.
2012;
7
(1):
118-27
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Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells.
Lujan E,
Chanda S, Ahlenius H, Südhof TC, Wernig M.
Proc Natl Acad Sci U S A.
2012;
109
(7):
2527-32
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Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission.
Xu W,
Morishita W, Buckmaster PS, Pang ZP, Malenka RC, Südhof TC.
Neuron.
2012;
73
(5):
990-1001
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High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex.
Boucard AA,
Ko J, Südhof TC.
J Biol Chem.
2012;
287
(12):
9399-413
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Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron.
Yang SN,
Shi Y, Yang G, Li Y, Yu L, Shin OH, Bacaj T, Südhof TC, Yu J, Berggren PO.
Proc Natl Acad Sci U S A.
2012;
109
(30):
12183-8
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Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex.
Narboux-Nême N,
Evrard A, Ferezou I, Erzurumlu RS, Kaeser PS, Lainé J, Rossier J, Ropert N, Südhof TC, Gaspar P.
J Neurosci.
2012;
32
(18):
6183-96
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Postsynaptic complexin controls AMPA receptor exocytosis during LTP.
Ahmad M,
Polepalli JS, Goswami D, Yang X, Kaeser-Woo YJ, Südhof TC, Malenka RC.
Neuron.
2012;
73
(2):
260-7
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Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
Sharma M,
Burré J, Südhof TC.
Sci Transl Med.
2012;
4
(147):
147ra113
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RIM genes differentially contribute to organizing presynaptic release sites.
Kaeser PS,
Deng L, Fan M, Südhof TC.
Proc Natl Acad Sci U S A.
2012;
109
(29):
11830-5
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Region-specific deletions of RIM1 reproduce a subset of global RIM1α(-/-) phenotypes.
Haws ME,
Kaeser PS, Jarvis DL, Südhof TC, Powell CM.
Genes Brain Behav.
2012;
11
(2):
201-13
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Synapses and Alzheimer's disease.
Sheng M,
Sabatini BL, Südhof TC.
Cold Spring Harb Perspect Biol.
2012;
4
(5)
-
Synaptic cell adhesion.
Missler M,
Südhof TC, Biederer T.
Cold Spring Harb Perspect Biol.
2012;
4
(4):
a005694
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Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.
Burré J,
Sharma M, Südhof TC.
J Neurosci.
2012;
32
(43):
15227-42
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The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?
Rizo J,
Südhof TC.
Annu Rev Cell Dev Biol.
2012:
28
279-308
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The presynaptic active zone.
Südhof TC,
Neuron.
2012;
75
(1):
11-25
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Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.
Cao P,
Maximov A, Südhof TC.
Cell.
2011;
145
(2):
300-11
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An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
Etherton MR,
Tabuchi K, Sharma M, Ko J, Südhof TC.
EMBO J.
2011;
30
(14):
2908-19
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Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.
Etherton M,
Földy C, Sharma M, Tabuchi K, Liu X, Shamloo M, Malenka RC, Südhof TC.
Proc Natl Acad Sci U S A.
2011;
108
(33):
13764-9
-
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Sharma M,
Burré J, Südhof TC.
Nat Cell Biol.
2011;
13
(2):
182
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CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Sharma M,
Burré J, Südhof TC.
Nat Cell Biol.
2011;
13
(1):
30-9
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Cerebellins meet neurexins (Commentary on Matsuda & Yuzaki).
Martinelli DC,
Südhof TC.
Eur J Neurosci.
2011;
33
(8):
1445-6
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Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes.
Gustavsson N,
Seah T, Lao Y, Radda GK, Südhof TC, Han W.
Diabetologia.
2011;
54
(2):
415-22
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Direct lineage conversion of terminally differentiated hepatocytes to functional neurons.
Marro S,
Pang ZP, Yang N, Tsai MC, Qu K, Chang HY, Südhof TC, Wernig M.
Cell Stem Cell.
2011;
9
(4):
374-82
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Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism.
Pang ZP,
Bacaj T, Yang X, Zhou P, Xu W, Südhof TC.
Neuron.
2011;
70
(2):
244-51
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Induced neuronal cells: how to make and define a neuron.
Yang N,
Ng YH, Pang ZP, Südhof TC, Wernig M.
Cell Stem Cell.
2011;
9
(6):
517-25
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Induction of human neuronal cells by defined transcription factors.
Pang ZP,
Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M.
Nature.
2011;
476
(7359):
220-3
-
Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons.
Ko J,
Soler-Llavina GJ, Fuccillo MV, Malenka RC, Südhof TC.
J Cell Biol.
2011;
194
(2):
323-34
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RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone.
Han Y,
Kaeser PS, Südhof TC, Schneggenburger R.
Neuron.
2011;
69
(2):
304-16
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RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.
Deng L,
Kaeser PS, Xu W, Südhof TC.
Neuron.
2011;
69
(2):
317-31
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RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction.
Kaeser PS,
Deng L, Wang Y, Dulubova I, Liu X, Rizo J, Südhof TC.
Cell.
2011;
144
(2):
282-95
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Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning.
Tsetsenis T,
Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Südhof TC.
Proc Natl Acad Sci U S A.
2011;
108
(34):
14300-5
-
Synaptic vesicle exocytosis.
Südhof TC,
Rizo J.
Cold Spring Harb Perspect Biol.
2011;
3
(12)
-
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins.
Bolliger MF,
Martinelli DC, Südhof TC.
Proc Natl Acad Sci U S A.
2011;
108
(6):
2534-9
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The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo.
Soler-Llavina GJ,
Fuccillo MV, Ko J, Südhof TC, Malenka RC.
Proc Natl Acad Sci U S A.
2011;
108
(40):
16502-9
-
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
Burré J,
Sharma M, Tsetsenis T, Buchman V, Etherton MR, Südhof TC.
Science.
2010;
329
(5999):
1663-7
-
An interview with Tom Südhof.
Südhof T,
Lancet.
2010;
376
(9739):
409
-
An interview with the Kavli prize winners. Interview by Claudia Wiedemann.
Rothman J,
Scheller R, Südhof T.
Nat Rev Neurosci.
2010;
11
(10):
669-73
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Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.
Pang ZP,
Cao P, Xu W, Südhof TC.
J Neurosci.
2010;
30
(11):
4132-42
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Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.
Pang ZP,
Xu W, Cao P, Südhof TC.
J Biol Chem.
2010;
285
(44):
33930-9
-
Cell biology of Ca2+-triggered exocytosis.
Pang ZP,
Südhof TC.
Curr Opin Cell Biol.
2010;
22
(4):
496-505
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Climate change and the integrity of science.
Gleick PH,
Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, Berenbaum MR, Berlin OB, Bjorkman PJ, Blackburn E, Blamont JE, Botchan MR, Boyer JS, Boyle EA, Branton D, Briggs SP, Briggs WR, Brill WJ, Britten RJ, Broecker WS, Brown JH, Brown PO, Brunger AT, Cairns J, Canfield DE, Carpenter SR, Carrington JC, Cashmore AR, Castilla JC, Cazenave A, Chapin FS, Ciechanover AJ, Clapham DE, Clark WC, Clayton RN, Coe MD, Conwell EM, Cowling EB, Cowling RM, Cox CS, Croteau RB, Crothers DM, Crutzen PJ, Daily GC, Dalrymple GB, Dangl JL, Darst SA, Davies DR, Davis MB, De Camilli PV, Dean C, DeFries RS, Deisenhofer J, Delmer DP, DeLong EF, DeRosier DJ, Diener TO, Dirzo R, Dixon JE, Donoghue MJ, Doolittle RF, Dunne T, Ehrlich PR, Eisenstadt SN, Eisner T, Emanuel KA, Englander SW, Ernst WG, Falkowski PG, Feher G, Ferejohn JA, Fersht A, Fischer EH, Fischer R, Flannery KV, Frank J, Frey PA, Fridovich I, Frieden C, Futuyma DJ, Gardner WR, Garrett CJ, Gilbert W, Goldberg RB, Goodenough WH, Goodman CS, Goodman M, Greengard P, Hake S, Hammel G, Hanson S, Harrison SC, Hart SR, Hartl DL, Haselkorn R, Hawkes K, Hayes JM, Hille B, Hökfelt T, House JS, Hout M, Hunten DM, Izquierdo IA, Jagendorf AT, Janzen DH, Jeanloz R, Jencks CS, Jury WA, Kaback HR, Kailath T, Kay P, Kay SA, Kennedy D, Kerr A, Kessler RC, Khush GS, Kieffer SW, Kirch PV, Kirk K, Kivelson MG, Klinman JP, Klug A, Knopoff L, Kornberg H, Kutzbach JE, Lagarias JC, Lambeck K, Landy A, Langmuir CH, Larkins BA, Le Pichon XT, Lenski RE, Leopold EB, Levin SA, Levitt M, Likens GE, Lippincott-Schwartz J, Lorand L, Lovejoy CO, Lynch M, Mabogunje AL, Malone TF, Manabe S, Marcus J, Massey DS, McWilliams JC, Medina E, Melosh HJ, Meltzer DJ, Michener CD, Miles EL, Mooney HA, Moore PB, Morel FM, Mosley-Thompson ES, Moss B, Munk WH, Myers N, Nair GB, Nathans J, Nester EW, Nicoll RA, Novick RP, O'Connell JF, Olsen PE, Opdyke ND, Oster GF, Ostrom E, Pace NR, Paine RT, Palmiter RD, Pedlosky J, Petsko GA, Pettengill GH, Philander SG, Piperno DR, Pollard TD, Price PB, Reichard PA, Reskin BF, Ricklefs RE, Rivest RL, Roberts JD, Romney AK, Rossmann MG, Russell DW, Rutter WJ, Sabloff JA, Sagdeev RZ, Sahlins MD, Salmond A, Sanes JR, Schekman R, Schellnhuber J, Schindler DW, Schmitt J, Schneider SH, Schramm VL, Sederoff RR, Shatz CJ, Sherman F, Sidman RL, Sieh K, Simons EL, Singer BH, Singer MF, Skyrms B, Sleep NH, Smith BD, Snyder SH, Sokal RR, Spencer CS, Steitz TA, Strier KB, Südhof TC, Taylor SS, Terborgh J, Thomas DH, Thompson LG, Tjian RT, Turner MG, Uyeda S, Valentine JW, Valentine JS, Van Etten JL, van Holde KE, Vaughan M, Verba S, von Hippel PH, Wake DB, Walker A, Walker JE, Watson EB, Watson PJ, Weigel D, Wessler SR, West-Eberhard MJ, White TD, Wilson WJ, Wolfenden RV, Wood JA, Woodwell GM, Wright HE, Wu C, Wunsch C, Zoback ML.
Science.
2010;
328
(5979):
689-90
-
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix.
Yang X,
Kaeser-Woo YJ, Pang ZP, Xu W, Südhof TC.
Neuron.
2010;
68
(5):
907-20
-
Direct conversion of fibroblasts to functional neurons by defined factors.
Vierbuchen T,
Ostermeier A, Pang ZP, Kokubu Y, Südhof TC, Wernig M.
Nature.
2010;
463
(7284):
1035-41
-
Evolution of CASK into a Mg2+-sensitive kinase.
Mukherjee K,
Sharma M, Jahn R, Wahl MC, Südhof TC.
Sci Signal.
2010;
3
(119):
ra33
-
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.
Li H,
Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Südhof TC, Wang R, Zheng H.
J Biol Chem.
2010;
285
(40):
30598-605
-
Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction.
Zhang D,
Zhang C, Ho A, Kirkwood A, Südhof TC, Shen J.
J Neurochem.
2010;
115
(5):
1215-21
-
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Shin OH,
Lu J, Rhee JS, Tomchick DR, Pang ZP, Wojcik SM, Camacho-Perez M, Brose N, Machius M, Rizo J, Rosenmund C, Südhof TC.
Nat Struct Mol Biol.
2010;
17
(3):
280-8
-
Neurexins physically and functionally interact with GABA(A) receptors.
Zhang C,
Atasoy D, Araç D, Yang X, Fucillo MV, Robison AJ, Ko J, Brunger AT, Südhof TC.
Neuron.
2010;
66
(3):
403-16
-
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior.
Blundell J,
Blaiss CA, Etherton MR, Espinosa F, Tabuchi K, Walz C, Bolliger MF, Südhof TC, Powell CM.
J Neurosci.
2010;
30
(6):
2115-29
-
Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion.
Gustavsson N,
Wang X, Wang Y, Seah T, Xu J, Radda GK, Südhof TC, Han W.
PLoS One.
2010;
5
(11):
e15414
-
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis.
Mukherjee K,
Yang X, Gerber SH, Kwon HB, Ho A, Castillo PE, Liu X, Südhof TC.
Proc Natl Acad Sci U S A.
2010;
107
(14):
6504-9
-
Push-and-pull regulation of the fusion pore by synaptotagmin-7.
Segovia M,
Alés E, Montes MA, Bonifas I, Jemal I, Lindau M, Maximov A, Südhof TC, Alvarez de Toledo G.
Proc Natl Acad Sci U S A.
2010;
107
(44):
19032-7
-
QnAs with Thomas C. Südhof. Interview by Prashant Nair.
Südhof TC,
Proc Natl Acad Sci U S A.
2010;
107
(42):
17863
-
RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia.
Blundell J,
Kaeser PS, Südhof TC, Powell CM.
J Neurosci.
2010;
30
(15):
5326-33
-
Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells.
Schonn JS,
van Weering JR, Mohrmann R, Schlüter OM, Südhof TC, de Wit H, Verhage M, Sørensen JB.
Traffic.
2010;
11
(11):
1415-28
-
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.
Li H,
Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Südhof TC, Zheng H.
Proc Natl Acad Sci U S A.
2010;
107
(40):
17362-7
-
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M,
Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J.
PLoS One.
2010;
5
(9)
-
SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning.
Robbins EM,
Krupp AJ, Perez de Arce K, Ghosh AK, Fogel AI, Boucard A, Südhof TC, Stein V, Biederer T.
Neuron.
2010;
68
(5):
894-906
-
Testing the SNARE/SM protein model of membrane fusion.
Bacaj T,
Pang ZP, Südhof TC.
Proc Natl Acad Sci U S A.
2010;
107
(52):
22365-6
-
beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC.
Barbu EM,
Ganesh VK, Gurusiddappa S, Mackenzie RC, Foster TJ, Sudhof TC, Höök M.
PLoS Pathog.
2010;
6
(1):
e1000726
-
A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export.
Zhang C,
Milunsky JM, Newton S, Ko J, Zhao G, Maher TA, Tager-Flusberg H, Bolliger MF, Carter AS, Boucard AA, Powell CM, Südhof TC.
J Neurosci.
2009;
29
(35):
10843-54
-
Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery.
Deák F,
Liu X, Khvotchev M, Li G, Kavalali ET, Sugita S, Südhof TC.
J Neurosci.
2009;
29
(27):
8639-48
-
Common circuit defect of excitatory-inhibitory balance in mouse models of autism.
Gogolla N,
Leblanc JJ, Quast KB, Südhof TC, Fagiolini M, Hensch TK.
J Neurodev Disord.
2009;
1
(2):
172-81
-
Complexin controls the force transfer from SNARE complexes to membranes in fusion.
Maximov A,
Tang J, Yang X, Pang ZP, Südhof TC.
Science.
2009;
323
(5913):
516-21
-
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.
Tabuchi K,
Chen G, Südhof TC, Shen J.
J Neurosci.
2009;
29
(22):
7290-301
-
Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release.
Shin OH,
Xu J, Rizo J, Südhof TC.
Proc Natl Acad Sci U S A.
2009;
106
(38):
16469-74
-
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.
Kaeser PS,
Deng L, Chávez AE, Liu X, Castillo PE, Südhof TC.
Neuron.
2009;
64
(2):
227-39
-
Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2.
Blundell J,
Tabuchi K, Bolliger MF, Blaiss CA, Brose N, Liu X, Südhof TC, Powell CM.
Genes Brain Behav.
2009;
8
(1):
114-26
-
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation.
Ko J,
Fuccillo MV, Malenka RC, Südhof TC.
Neuron.
2009;
64
(6):
791-8
-
Membrane fusion: grappling with SNARE and SM proteins.
Südhof TC,
Rothman JE.
Science.
2009;
323
(5913):
474-7
-
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.
Etherton MR,
Blaiss CA, Powell CM, Südhof TC.
Proc Natl Acad Sci U S A.
2009;
106
(42):
17998-8003
-
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming.
Deák F,
Xu Y, Chang WP, Dulubova I, Khvotchev M, Liu X, Südhof TC, Rizo J.
J Cell Biol.
2009;
184
(5):
751-64
-
Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation.
Ko J,
Zhang C, Arac D, Boucard AA, Brunger AT, Südhof TC.
EMBO J.
2009;
28
(20):
3244-55
-
Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons.
Gibson JR,
Huber KM, Südhof TC.
J Neurosci.
2009;
29
(44):
13883-97
-
Presenilins are essential for regulating neurotransmitter release.
Zhang C,
Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J.
Nature.
2009;
460
(7255):
632-6
-
SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis.
Chang WP,
Südhof TC.
J Neurosci.
2009;
29
(4):
883-97
-
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release.
Xu J,
Pang ZP, Shin OH, Südhof TC.
Nat Neurosci.
2009;
12
(6):
759-66
-
Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas.
Gustavsson N,
Wei SH, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Südhof TC, Han W.
J Physiol.
2009;
587
(Pt 6):
1169-78
-
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.
Gallardo G,
Schlüter OM, Südhof TC.
Nat Neurosci.
2008;
11
(3):
301-8
-
CASK Functions as a Mg2+-independent neurexin kinase.
Mukherjee K,
Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC.
Cell.
2008;
133
(2):
328-39
-
Conformational switch of syntaxin-1 controls synaptic vesicle fusion.
Gerber SH,
Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC.
Science.
2008;
321
(5895):
1507-10
-
Cysteine string protein-alpha is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse.
Ruiz R,
Casañas JJ, Südhof TC, Tabares L.
Eur J Neurosci.
2008;
27
(12):
3118-31
-
Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.
Ho A,
Liu X, Südhof TC.
J Neurosci.
2008;
28
(53):
14392-400
-
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis.
Maximov A,
Lao Y, Li H, Chen X, Rizo J, Sørensen JB, Südhof TC.
Proc Natl Acad Sci U S A.
2008;
105
(10):
3986-91
-
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice.
Gustavsson N,
Lao Y, Maximov A, Chuang JC, Kostromina E, Repa JJ, Li C, Radda GK, Südhof TC, Han W.
Proc Natl Acad Sci U S A.
2008;
105
(10):
3992-7
-
Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC,
Nature.
2008;
455
(7215):
903-11
-
RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions.
Kaeser PS,
Kwon HB, Chiu CQ, Deng L, Castillo PE, Südhof TC.
J Neurosci.
2008;
28
(50):
13435-47
-
RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning.
Kaeser PS,
Kwon HB, Blundell J, Chevaleyre V, Morishita W, Malenka RC, Powell CM, Castillo PE, Südhof TC.
Proc Natl Acad Sci U S A.
2008;
105
(38):
14680-5
-
Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells.
Schonn JS,
Maximov A, Lao Y, Südhof TC, Sørensen JB.
Proc Natl Acad Sci U S A.
2008;
105
(10):
3998-4003
-
Understanding synapses: past, present, and future.
Südhof TC,
Malenka RC.
Neuron.
2008;
60
(3):
469-76
-
Unusually rapid evolution of Neuroligin-4 in mice.
Bolliger MF,
Pei J, Maxeiner S, Boucard AA, Grishin NV, Südhof TC.
Proc Natl Acad Sci U S A.
2008;
105
(17):
6421-6
-
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse.
Sun J,
Pang ZP, Qin D, Fahim AT, Adachi R, Südhof TC.
Nature.
2007;
450
(7170):
676-82
-
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K,
Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC.
Science.
2007;
318
(5847):
71-6
-
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.
Chubykin AA,
Atasoy D, Etherton MR, Brose N, Kavalali ET, Gibson JR, Südhof TC.
Neuron.
2007;
54
(6):
919-31
-
Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.
Guan R,
Dai H, Tomchick DR, Dulubova I, Machius M, Südhof TC, Rizo J.
Biochemistry.
2007;
46
(31):
8988-98
-
Deletion of CASK in mice is lethal and impairs synaptic function.
Atasoy D,
Schoch S, Ho A, Nadasy KA, Liu X, Zhang W, Mukherjee K, Nosyreva ED, Fernandez-Chacon R, Missler M, Kavalali ET, Südhof TC.
Proc Natl Acad Sci U S A.
2007;
104
(7):
2525-30
-
Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.
Dudanova I,
Tabuchi K, Rohlmann A, Südhof TC, Missler M.
J Comp Neurol.
2007;
502
(2):
261-74
-
Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission.
Bronk P,
Deák F, Wilson MC, Liu X, Südhof TC, Kavalali ET.
J Neurophysiol.
2007;
98
(2):
794-806
-
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.
Khvotchev M,
Dulubova I, Sun J, Dai H, Rizo J, Südhof TC.
J Neurosci.
2007;
27
(45):
12147-55
-
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.
Min SW,
Chang WP, Südhof TC.
Proc Natl Acad Sci U S A.
2007;
104
(10):
3823-8
-
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
Chevaleyre V,
Heifets BD, Kaeser PS, Südhof TC, Purpura DP, Castillo PE.
Neuron.
2007;
54
(5):
801-12
-
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines.
Wu H,
Xu J, Pang ZP, Ge W, Kim KJ, Blanchi B, Chen C, Südhof TC, Sun YE.
Proc Natl Acad Sci U S A.
2007;
104
(34):
13821-6
-
Membrane fusion as a team effort.
Südhof TC,
Proc Natl Acad Sci U S A.
2007;
104
(34):
13541-2
-
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation.
Maximov A,
Pang ZP, Tervo DG, Südhof TC.
J Neurosci Methods.
2007;
161
(1):
75-87
-
Munc18-1 binds directly to the neuronal SNARE complex.
Dulubova I,
Khvotchev M, Liu S, Huryeva I, Südhof TC, Rizo J.
Proc Natl Acad Sci U S A.
2007;
104
(8):
2697-702
-
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions.
Araç D,
Boucard AA, Ozkan E, Strop P, Newell E, Südhof TC, Brunger AT.
Neuron.
2007;
56
(6):
992-1003
-
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons.
Xu J,
Mashimo T, Südhof TC.
Neuron.
2007;
54
(4):
567-81
-
Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release.
Maximov A,
Shin OH, Liu X, Südhof TC.
J Cell Biol.
2007;
176
(1):
113-24
-
cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map.
Nicol X,
Voyatzis S, Muzerelle A, Narboux-Nême N, Südhof TC, Miles R, Gaspar P.
Nat Neurosci.
2007;
10
(3):
340-7
-
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
Tang J,
Maximov A, Shin OH, Dai H, Rizo J, Südhof TC.
Cell.
2006;
126
(6):
1175-87
-
A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.
Pang ZP,
Shin OH, Meyer AC, Rosenmund C, Südhof TC.
J Neurosci.
2006;
26
(48):
12556-65
-
CSPalpha-deficiency causes massive and rapid photoreceptor degeneration.
Schmitz F,
Tabares L, Khimich D, Strenzke N, de la Villa-Polo P, Castellano-Muñoz M, Bulankina A, Moser T, Fernández-Chacón R, Südhof TC.
Proc Natl Acad Sci U S A.
2006;
103
(8):
2926-31
-
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids.
Araç D,
Chen X, Khant HA, Ubach J, Ludtke SJ, Kikkawa M, Johnson AE, Chiu W, Südhof TC, Rizo J.
Nat Struct Mol Biol.
2006;
13
(3):
209-17
-
Crystal structure of the second LNS/LG domain from neurexin 1alpha: Ca2+ binding and the effects of alternative splicing.
Sheckler LR,
Henry L, Sugita S, Südhof TC, Rudenko G.
J Biol Chem.
2006;
281
(32):
22896-905
-
Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation.
Nagy G,
Kim JH, Pang ZP, Matti U, Rettig J, Südhof TC, Sørensen JB.
J Neurosci.
2006;
26
(2):
632-43
-
Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification.
Juranek J,
Mukherjee K, Rickmann M, Martens H, Calka J, Südhof TC, Jahn R.
Eur J Neurosci.
2006;
24
(11):
3043-52
-
Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins.
Comoletti D,
Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Südhof TC, Taylor P.
Biochemistry.
2006;
45
(42):
12816-27
-
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.
Ho A,
Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer RE, Malenka RC, Südhof TC.
J Neurosci.
2006;
26
(50):
13089-101
-
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release.
Pang ZP,
Sun J, Rizo J, Maximov A, Südhof TC.
EMBO J.
2006;
25
(10):
2039-50
-
Neuroligins determine synapse maturation and function.
Varoqueaux F,
Aramuni G, Rawson RL, Mohrmann R, Missler M, Gottmann K, Zhang W, Südhof TC, Brose N.
Neuron.
2006;
51
(6):
741-54
-
Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1.
Li L,
Shin OH, Rhee JS, Araç D, Rah JC, Rizo J, Südhof T, Rosenmund C.
J Biol Chem.
2006;
281
(23):
15845-52
-
Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.
Schlüter OM,
Basu J, Südhof TC, Rosenmund C.
J Neurosci.
2006;
26
(4):
1239-46
-
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion.
Deák F,
Shin OH, Tang J, Hanson P, Ubach J, Jahn R, Rizo J, Kavalali ET, Südhof TC.
EMBO J.
2006;
25
(12):
2856-66
-
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
Schoch S,
Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Südhof TC.
EMBO J.
2006;
25
(24):
5852-63
-
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.
Lu J,
Machius M, Dulubova I, Dai H, Südhof TC, Tomchick DR, Rizo J.
PLoS Biol.
2006;
4
(7):
e192
-
Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion.
Deák F,
Shin OH, Kavalali ET, Südhof TC.
J Neurosci.
2006;
26
(25):
6668-76
-
Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway.
Sun J,
Bronk P, Liu X, Han W, Südhof TC.
Proc Natl Acad Sci U S A.
2006;
103
(8):
2880-5
-
Synaptic vesicles: an organelle comes of age.
Südhof TC,
Cell.
2006;
127
(4):
671-3
-
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses.
Pang ZP,
Melicoff E, Padgett D, Liu Y, Teich AF, Dickey BF, Lin W, Adachi R, Südhof TC.
J Neurosci.
2006;
26
(52):
13493-504
-
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
Dulubova I,
Lou X, Lu J, Huryeva I, Alam A, Schneggenburger R, Südhof TC, Rizo J.
EMBO J.
2005;
24
(16):
2839-50
-
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins.
Boucard AA,
Chubykin AA, Comoletti D, Taylor P, Südhof TC.
Neuron.
2005;
48
(2):
229-36
-
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.
Chandra S,
Gallardo G, Fernández-Chacón R, Schlüter OM, Südhof TC.
Cell.
2005;
123
(3):
383-96
-
Are neuronal SNARE proteins Ca2+ sensors?
Chen X,
Tang J, Sudhof TC, Rizo J.
J Mol Biol.
2005;
347
(1):
145-58
-
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1.
Rhee JS,
Li LY, Shin OH, Rah JC, Rizo J, Südhof TC, Rosenmund C.
Proc Natl Acad Sci U S A.
2005;
102
(51):
18664-9
-
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release.
Maximov A,
Südhof TC.
Neuron.
2005;
48
(4):
547-54
-
C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1.
Han W,
Rhee JS, Maximov A, Lin W, Hammer RE, Rosenmund C, Südhof TC.
J Biol Chem.
2005;
280
(6):
5089-100
-
CAPS in search of a lost function.
Südhof TC,
Neuron.
2005;
46
(1):
2-4
-
Crystal structure of the RIM2 C2A-domain at 1.4 A resolution.
Dai H,
Tomchick DR, García J, Südhof TC, Machius M, Rizo J.
Biochemistry.
2005;
44
(41):
13533-42
-
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
Chubykin AA,
Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC.
J Biol Chem.
2005;
280
(23):
22365-74
-
Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties.
Shin OH,
Han W, Wang Y, Südhof TC.
J Biol Chem.
2005;
280
(2):
1641-51
-
Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels.
Zhang W,
Rohlmann A, Sargsyan V, Aramuni G, Hammer RE, Südhof TC, Missler M.
J Neurosci.
2005;
25
(17):
4330-42
-
Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation.
Huang YY,
Zakharenko SS, Schoch S, Kaeser PS, Janz R, Südhof TC, Siegelbaum SA, Kandel ER.
Proc Natl Acad Sci U S A.
2005;
102
(26):
9365-70
-
Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation.
Toonen RF,
de Vries KJ, Zalm R, Südhof TC, Verhage M.
J Neurochem.
2005;
93
(6):
1393-400
-
Nicastrin functions as a gamma-secretase-substrate receptor.
Shah S,
Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE, Südhof T, Yu G.
Cell.
2005;
122
(3):
435-47
-
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein.
Fornai F,
Schlüter OM, Lenzi P, Gesi M, Ruffoli R, Ferrucci M, Lazzeri G, Busceti CL, Pontarelli F, Battaglia G, Pellegrini A, Nicoletti F, Ruggieri S, Paparelli A, Südhof TC.
Proc Natl Acad Sci U S A.
2005;
102
(9):
3413-8
-
RIM function in short- and long-term synaptic plasticity.
Kaeser PS,
Südhof TC.
Biochem Soc Trans.
2005;
33
(Pt 6):
1345-9
-
Selective capability of SynCAM and neuroligin for functional synapse assembly.
Sara Y,
Biederer T, Atasoy D, Chubykin A, Mozhayeva MG, Südhof TC, Kavalali ET.
J Neurosci.
2005;
25
(1):
260-70
-
Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide.
Lu J,
Li H, Wang Y, Südhof TC, Rizo J.
J Mol Biol.
2005;
352
(2):
455-66
-
v-SNAREs control exocytosis of vesicles from priming to fusion.
Borisovska M,
Zhao Y, Tsytsyura Y, Glyvuk N, Takamori S, Matti U, Rettig J, Südhof T, Bruns D.
EMBO J.
2005;
24
(12):
2114-26
-
Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release.
Calakos N,
Schoch S, Südhof TC, Malenka RC.
Neuron.
2004;
42
(6):
889-96
-
Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.
Schlüter OM,
Fornai F, Alessandrí MG, Takamori S, Geppert M, Jahn R, Südhof TC.
Neuroscience.
2003;
118
(4):
985-1002
-
RIM1alpha is required for presynaptic long-term potentiation.
Castillo PE,
Schoch S, Schmitz F, Südhof TC, Malenka RC.
Nature.
2002;
415
(6869):
327-30
-
Mapping of synapsin II (SYN2) genes to human chromosome 3p and mouse chromosome 6 band F.
Li X,
Rosahl TW, Südhof TC, Francke U.
Cytogenet Cell Genet.
1995;
71
(3):
301-5
-
Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse.
Ozçelik T,
Lafreniere RG, Archer BT, Johnston PA, Willard HF, Francke U, Südhof TC.
Am J Hum Genet.
1990;
47
(3):
551-61
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