Joanna Wysocka

Publications

• Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest. Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J. Cell Stem Cell. 2012; 11 (5): 633-48
• A unique chromatin signature uncovers early developmental enhancers in humans. Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J. Nature. 2011; 470 (7333): 279-83
• Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates. Ma Z, Swigut T, Valouev A, Rada-Iglesias A, Wysocka J. Nat Struct Mol Biol. 2011; 18 (2): 120-7
• CHD7 cooperates with PBAF to control multipotent neural crest formation. Bajpai R, Chen DA, Rada-Iglesias A, Zhang J, Xiong Y, Helms J, Chang CP, Zhao Y, Swigut T, Wysocka J. Nature. 2010; 463 (7283): 958-62
• Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. Nature. 2009; 458 (7237): 529-33
• Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J. Cell. 2009; 139 (7): 1290-302
• E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases. Tyagi S, Chabes AL, Wysocka J, Herr W. Mol Cell. 2007; 27 (1): 107-19
• H3K27 demethylases, at long last. Swigut T, Wysocka J. Cell. 2007; 131 (1): 29-32
• Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Ruthenburg AJ, Allis CD, Wysocka J. Mol Cell. 2007; 25 (1): 15-30
• A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD. Nature. 2006; 442 (7098): 86-90
• WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG, Brivanlou AH, Allis CD. Cell. 2005; 121 (6): 859-72
• Enhancers as information integration hubs in development: lessons from genomics. Buecker C, Wysocka J. Trends Genet. 2012; 28 (6): 276-84
• A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, Lajoie BR, Protacio A, Flynn RA, Gupta RA, Wysocka J, Lei M, Dekker J, Helms JA, Chang HY. Nature. 2011; 472 (7341): 120-4
• Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease. Rada-Iglesias A, Wysocka J. Genome Med. 2011; 3 (6): 36
• Flipping MLL1's switch one proline at a time. Grow EJ, Wysocka J. Cell. 2010; 141 (7): 1108-10
• Fallen immortals. Swigut T, Wysocka J. Cell. 2009; 137 (2): 203-5
• It takes a PHD to SUMO. Peng J, Wysocka J. Trends Biochem Sci. 2008; 33 (5): 191-4
• Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells. Lee S, Horn V, Julien E, Liu Y, Wysocka J, Bowerman B, Hengartner MO, Herr W. PLoS One. 2007; 2 (11): e1213
• Histone arginine methylation and its dynamic regulation. Wysocka J, Allis CD, Coonrod S. Front Biosci. 2006: 11 344-55
• Identifying novel proteins recognizing histone modifications using peptide pull-down assay. Wysocka J, Methods. 2006; 40 (4): 339-43
• Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Li H, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD, Patel DJ. Nature. 2006; 442 (7098): 91-5
• Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG. Cell. 2005; 121 (6): 873-85
• Taking LSD 1 to a new high. Wysocka J, Milne TA, Allis CD. Cell. 2005; 122 (5): 654-8
• Human PAD4 regulates histone arginine methylation levels via demethylimination. Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD, Coonrod SA. Science. 2004; 306 (5694): 279-83
• Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML. Mol Cell Biol. 2004; 24 (13): 5639-49
• Linking covalent histone modifications to epigenetics: the rigidity and plasticity of the marks. Wang Y, Wysocka J, Perlin JR, Leonelli L, Allis CD, Coonrod SA. Cold Spring Harb Symp Quant Biol. 2004: 69 161-9
• Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W. Genes Dev. 2003; 17 (7): 896-911
• The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. Wysocka J, Herr W. Trends Biochem Sci. 2003; 28 (6): 294-304
• Inactivation of the retinoblastoma protein family can bypass the HCF-1 defect in tsBN67 cell proliferation and cytokinesis. Reilly PT, Wysocka J, Herr W. Mol Cell Biol. 2002; 22 (19): 6767-78
• Developmental and cell-cycle regulation of Caenorhabditis elegans HCF phosphorylation. Wysocka J, Liu Y, Kobayashi R, Herr W. Biochemistry. 2001; 40 (19): 5786-94
• Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells. Wysocka J, Reilly PT, Herr W. Mol Cell Biol. 2001; 21 (11): 3820-9