Publications
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A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors.
Piccione EC,
Lieu TJ, Gentile CF, Williams TR, Connolly AJ, Godwin AK, Koong AC, Wong AJ.
Oncogene.
2012;
31
(24):
2953-67
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EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms.
Del Vecchio CA,
Giacomini CP, Vogel H, Jensen KC, Florio T, Merlo A, Pollack JR, Wong AJ.
Oncogene.
2012
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Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma.
Del Vecchio CA,
Jensen KC, Nitta RT, Shain AH, Giacomini CP, Wong AJ.
Cancer Res.
2012;
72
(10):
2657-71
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Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas.
Li G,
Mitra SS, Monje M, Henrich KN, Bangs CD, Nitta RT, Wong AJ.
J Neurooncol.
2012;
108
(3):
395-402
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Targeting EGF receptor variant III: tumor-specific peptide vaccination for malignant gliomas.
Del Vecchio CA,
Li G, Wong AJ.
Expert Rev Vaccines.
2012;
11
(2):
133-44
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Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma.
Monje M,
Mitra SS, Freret ME, Raveh TB, Kim J, Masek M, Attema JL, Li G, Haddix T, Edwards MS, Fisher PG, Weissman IL, Rowitch DH, Vogel H, Wong AJ, Beachy PA.
Proc Natl Acad Sci U S A.
2011;
108
(11):
4453-8
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The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis.
Nitta RT,
Del Vecchio CA, Chu AH, Mitra SS, Godwin AK, Wong AJ.
Oncogene.
2011;
30
(2):
234-44
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Development of an EGFRvIII specific recombinant antibody.
Gupta P,
Han SY, Holgado-Madruga M, Mitra SS, Li G, Nitta RT, Wong AJ.
BMC Biotechnol.
2010:
10
72
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Measuring the constitutive activation of c-Jun N-terminal kinase isoforms.
Nitta RT,
Badal SS, Wong AJ.
Methods Enzymol.
2010:
484
531-48
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Pineal parenchymal tumor of intermediate differentiation: clinicopathological report and analysis of epidermal growth factor receptor variant III expression.
Li G,
Mitra S, Karamchandani J, Edwards MS, Wong AJ.
Neurosurgery.
2010;
66
(5):
963-8; discussion 968
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Rindopepimut, a 14-mer injectable peptide vaccine against EGFRvIII for the potential treatment of glioblastoma multiforme.
Del Vecchio CA,
Wong AJ.
Curr Opin Mol Ther.
2010;
12
(6):
741-54
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The epidermal growth factor variant III peptide vaccine for treatment of malignant gliomas.
Li G,
Mitra S, Wong AJ.
Neurosurg Clin N Am.
2010;
21
(1):
87-93
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Constitutive activity of JNK2 alpha2 is dependent on a unique mechanism of MAPK activation.
Nitta RT,
Chu AH, Wong AJ.
J Biol Chem.
2008;
283
(50):
34935-45
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EGF receptor variant III as a target antigen for tumor immunotherapy.
Li G,
Wong AJ.
Expert Rev Vaccines.
2008;
7
(7):
977-85
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The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.
Laramée M,
Chabot C, Cloutier M, Stenne R, Holgado-Madruga M, Wong AJ, Royal I.
J Biol Chem.
2007;
282
(11):
7758-69
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Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment.
Goel HL,
Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR.
Cancer Res.
2006;
66
(1):
331-42
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c-Jun NH(2)-terminal kinase 2alpha2 promotes the tumorigenicity of human glioblastoma cells.
Cui J,
Han SY, Wang C, Su W, Harshyne L, Holgado-Madruga M, Wong AJ.
Cancer Res.
2006;
66
(20):
10024-31
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Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes.
Sun H,
Shen Y, Dokainish H, Holgado-Madruga M, Wong A, Ireton K.
Cell Microbiol.
2005;
7
(3):
443-57
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Identification of a specific domain responsible for JNK2alpha2 autophosphorylation.
Cui J,
Holgado-Madruga M, Su W, Tsuiki H, Wedegaertner P, Wong AJ.
J Biol Chem.
2005;
280
(11):
9913-20
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Alterations in the expression of androgen receptor, wild type-epidermal growth factor receptor and a mutant epidermal growth factor receptor in human prostate cancer.
Olapade-Olaopa EO,
Moscatello DK, MacKay EH, Sandhu DP, Terry TR, Wong AJ, Habib FK.
Afr J Med Med Sci.
2004;
33
(3):
245-53
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Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation.
Holgado-Madruga M,
Wong AJ.
Cancer Res.
2004;
64
(6):
2007-15
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Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors.
Tsuiki H,
Tnani M, Okamoto I, Kenyon LC, Emlet DR, Holgado-Madruga M, Lanham IS, Joynes CJ, Vo KT, Wong AJ.
Cancer Res.
2003;
63
(1):
250-5
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Expression of constitutively activated EGFRvIII in non-small cell lung cancer.
Okamoto I,
Kenyon LC, Emlet DR, Mori T, Sasaki J, Hirosako S, Ichikawa Y, Kishi H, Godwin AK, Yoshioka M, Suga M, Matsumoto M, Wong AJ.
Cancer Sci.
2003;
94
(1):
50-6
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Gab1 is an integrator of cell death versus cell survival signals in oxidative stress.
Holgado-Madruga M,
Wong AJ.
Mol Cell Biol.
2003;
23
(13):
4471-84
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Targeting of cells expressing wild-type EGFR and type-III mutant EGFR (EGFRvIII) by anti-EGFR MAb ICR62: a two-pronged attack for tumour therapy.
Modjtahedi H,
Moscatello DK, Box G, Green M, Shotton C, Lamb DJ, Reynolds LJ, Wong AJ, Dean C, Thomas H, Eccles S.
Int J Cancer.
2003;
105
(2):
273-80
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Elevated JNK activation contributes to the pathogenesis of human brain tumors.
Antonyak MA,
Kenyon LC, Godwin AK, James DC, Emlet DR, Okamoto I, Tnani M, Holgado-Madruga M, Moscatello DK, Wong AJ.
Oncogene.
2002;
21
(33):
5038-46
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Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors.
Okamoto I,
Tsuiki H, Kenyon LC, Godwin AK, Emlet DR, Holgado-Madruga M, Lanham IS, Joynes CJ, Vo KT, Guha A, Matsumoto M, Ushio Y, Saya H, Wong AJ.
Am J Pathol.
2002;
160
(2):
441-7
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Further characterization of storage-related alterations in immunoreactivity of archival tissue sections and its implications for collaborative multicenter immunohistochemical studies.
Olapade-Olaopa EO,
Ogunbiyi JO, MacKay EH, Muronda CA, Alonge TO, Danso AP, Moscatello DK, Sandhu DP, Shittu OB, Terry TR, Wong AJ, Habib FK.
Appl Immunohistochem Mol Morphol.
2001;
9
(3):
261-6
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Grb-2-associated binder-1 is involved in insulin-induced egr-1 gene expression through its phosphatidylinositol 3'-kinase binding site.
Harada S,
Esch GL, Holgado-Madruga M, Wong AJ.
DNA Cell Biol.
2001;
20
(4):
223-9
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New approaches to the molecular biology, classification, and therapy of nervous system tumors: a workshop of the National Institutes of Health Pathology B study section.
Wong AJ,
Padarathsingh M, Louis DN, Rempel S, Ladisch S, Gladson C.
Am J Pathol.
2001;
159
(5):
1971-4
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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway.
Okamoto I,
Kawano Y, Murakami D, Sasayama T, Araki N, Miki T, Wong AJ, Saya H.
J Cell Biol.
2001;
155
(5):
755-62
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The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.
Ingham RJ,
Santos L, Dang-Lawson M, Holgado-Madruga M, Dudek P, Maroun CR, Wong AJ, Matsuuchi L, Gold MR.
J Biol Chem.
2001;
276
(15):
12257-65
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Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer.
Tang CK,
Gong XQ, Moscatello DK, Wong AJ, Lippman ME.
Cancer Res.
2000;
60
(11):
3081-7
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Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer.
Olapade-Olaopa EO,
Moscatello DK, MacKay EH, Horsburgh T, Sandhu DP, Terry TR, Wong AJ, Habib FK.
Br J Cancer.
2000;
82
(1):
186-94
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The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.
Maroun CR,
Naujokas MA, Holgado-Madruga M, Wong AJ, Park M.
Mol Cell Biol.
2000;
20
(22):
8513-25
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1998 Neurotumor Club. March 30, 1998, New Orleans, La.
Gladson CL,
Guha A, Wong AJ.
Neuro Oncol.
1999;
1
(1):
30-2
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A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis.
Maroun CR,
Moscatello DK, Naujokas MA, Holgado-Madruga M, Wong AJ, Park M.
J Biol Chem.
1999;
274
(44):
31719-26
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Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.
Bruening W,
Prowse AH, Schultz DC, Holgado-Madruga M, Wong A, Godwin AK.
Cancer Res.
1999;
59
(19):
4973-83
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Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells.
Korhonen JM,
Saïd FA, Wong AJ, Kaplan DR.
J Biol Chem.
1999;
274
(52):
37307-14
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The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase.
Maroun CR,
Holgado-Madruga M, Royal I, Naujokas MA, Fournier TM, Wong AJ, Park M.
Mol Cell Biol.
1999;
19
(3):
1784-99
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Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor.
Antonyak MA,
Moscatello DK, Wong AJ.
J Biol Chem.
1998;
273
(5):
2817-22
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Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor.
Moscatello DK,
Holgado-Madruga M, Emlet DR, Montgomery RB, Wong AJ.
J Biol Chem.
1998;
273
(1):
200-6
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Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
Moscatello DK,
Santra M, Mann DM, McQuillan DJ, Wong AJ, Iozzo RV.
J Clin Invest.
1998;
101
(2):
406-12
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Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules.
Rocchi S,
Tartare-Deckert S, Murdaca J, Holgado-Madruga M, Wong AJ, Van Obberghen E.
Mol Endocrinol.
1998;
12
(7):
914-23
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The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.
Ingham RJ,
Holgado-Madruga M, Siu C, Wong AJ, Gold MR.
J Biol Chem.
1998;
273
(46):
30630-7
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A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors.
Moscatello DK,
Ramirez G, Wong AJ.
Cancer Res.
1997;
57
(8):
1419-24
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Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.
Nguyen L,
Holgado-Madruga M, Maroun C, Fixman ED, Kamikura D, Fournier T, Charest A, Tremblay ML, Wong AJ, Park M.
J Biol Chem.
1997;
272
(33):
20811-9
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Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.
Fixman ED,
Holgado-Madruga M, Nguyen L, Kamikura DM, Fournier TM, Wong AJ, Park M.
J Biol Chem.
1997;
272
(32):
20167-72
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Epidermal growth factor receptor stimulation of diacylglycerol kinase.
Montgomery RB,
Moscatello DK, Wong AJ, Stahl WL.
Biochem Biophys Res Commun.
1997;
232
(1):
111-6
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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor.
Holgado-Madruga M,
Moscatello DK, Emlet DR, Dieterich R, Wong AJ.
Proc Natl Acad Sci U S A.
1997;
94
(23):
12419-24
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Subsets of epidermal growth factor receptors during activation and endocytosis.
Emlet DR,
Moscatello DK, Ludlow LB, Wong AJ.
J Biol Chem.
1997;
272
(7):
4079-86
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The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68.
Lawe DC,
Hahn C, Wong AJ.
Oncogene.
1997;
14
(2):
223-31
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A Grb2-associated docking protein in EGF- and insulin-receptor signalling.
Holgado-Madruga M,
Emlet DR, Moscatello DK, Godwin AK, Wong AJ.
Nature.
1996;
379
(6565):
560-4
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Identification of two candidate tumor suppressor genes on chromosome 17p13.3.
Schultz DC,
Vanderveer L, Berman DB, Hamilton TC, Wong AJ, Godwin AK.
Cancer Res.
1996;
56
(9):
1997-2002
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Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.
Moscatello DK,
Montgomery RB, Sundareshan P, McDanel H, Wong MY, Wong AJ.
Oncogene.
1996;
13
(1):
85-96
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Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor.
Montgomery RB,
Moscatello DK, Wong AJ, Cooper JA, Stahl WL.
J Biol Chem.
1995;
270
(51):
30562-6
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Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.
Moscatello DK,
Holgado-Madruga M, Godwin AK, Ramirez G, Gunn G, Zoltick PW, Biegel JA, Hayes RL, Wong AJ.
Cancer Res.
1995;
55
(23):
5536-9
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Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.
Wikstrand CJ,
Hale LP, Batra SK, Hill ML, Humphrey PA, Kurpad SN, McLendon RE, Moscatello D, Pegram CN, Reist CJ.
Cancer Res.
1995;
55
(14):
3140-8
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Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts.
Reist CJ,
Archer GE, Kurpad SN, Wikstrand CJ, Vaidyanathan G, Willingham MC, Moscatello DK, Wong AJ, Bigner DD, Zalutsky MR.
Cancer Res.
1995;
55
(19):
4375-82
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Polymorphism at codon 36 of the p53 gene.
Felix CA,
Brown DL, Mitsudomi T, Ikagaki N, Wong A, Wasserman R, Womer RB, Biegel JA.
Oncogene.
1994;
9
(1):
327-8
-
The molecular biology and molecular genetics of astrocytic neoplasms.
Wong AJ,
Zoltick PW, Moscatello DK.
Semin Oncol.
1994;
21
(2):
139-48
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Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.
Garcia de Palazzo IE,
Adams GP, Sundareshan P, Wong AJ, Testa JR, Bigner DD, Weiner LM.
Cancer Res.
1993;
53
(14):
3217-20
-
Oncogenes and signal transduction.
Wong AJ,
Croce CM.
Hosp Pract (Off Ed).
1993;
28
(7):
128-32, 136-8, 141
-
Structural alterations of the epidermal growth factor receptor gene in human gliomas.
Wong AJ,
Ruppert JM, Bigner SH, Grzeschik CH, Humphrey PA, Bigner DS, Vogelstein B.
Proc Natl Acad Sci U S A.
1992;
89
(7):
2965-9
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Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function.
Humphrey PA,
Gangarosa LM, Wong AJ, Archer GE, Lund-Johansen M, Bjerkvig R, Laerum OD, Friedman HS, Bigner DD.
Biochem Biophys Res Commun.
1991;
178
(3):
1413-20
-
Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.
Humphrey PA,
Wong AJ, Vogelstein B, Zalutsky MR, Fuller GN, Archer GE, Friedman HS, Kwatra MM, Bigner SH, Bigner DD.
Proc Natl Acad Sci U S A.
1990;
87
(11):
4207-11
-
Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.
Bigner SH,
Humphrey PA, Wong AJ, Vogelstein B, Mark J, Friedman HS, Bigner DD.
Cancer Res.
1990;
50
(24):
8017-22
-
Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.
Humphrey PA,
Wong AJ, Vogelstein B, Friedman HS, Werner MH, Bigner DD, Bigner SH.
Cancer Res.
1988;
48
(8):
2231-8
-
Gene amplification in malignant human gliomas: clinical and histopathologic aspects.
Bigner SH,
Burger PC, Wong AJ, Werner MH, Hamilton SR, Muhlbaier LH, Vogelstein B, Bigner DD.
J Neuropathol Exp Neurol.
1988;
47
(3):
191-205
-
The GLI-Kruppel family of human genes.
Ruppert JM,
Kinzler KW, Wong AJ, Bigner SH, Kao FT, Law ML, Seuanez HN, O'Brien SJ, Vogelstein B.
Mol Cell Biol.
1988;
8
(8):
3104-13
-
Identification of an amplified, highly expressed gene in a human glioma.
Kinzler KW,
Bigner SH, Bigner DD, Trent JM, Law ML, O'Brien SJ, Wong AJ, Vogelstein B.
Science.
1987;
236
(4797):
70-3
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Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.
Wong AJ,
Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B.
Proc Natl Acad Sci U S A.
1987;
84
(19):
6899-903
-
Relationship between gene amplification and chromosomal deviations in malignant human gliomas.
Bigner SH,
Wong AJ, Mark J, Muhlbaier LH, Kinzler KW, Vogelstein B, Bigner DD.
Cancer Genet Cytogenet.
1987;
29
(1):
165-70
-
Gene amplification of c-myc and N-myc in small cell carcinoma of the lung.
Wong AJ,
Ruppert JM, Eggleston J, Hamilton SR, Baylin SB, Vogelstein B.
Science.
1986;
233
(4762):
461-4
-
Disorganization of cultured vascular endothelial cell monolayers by fibrinogen fragment D.
Dang CV,
Bell WR, Kaiser D, Wong A.
Science.
1985;
227
(4693):
1487-90
-
Myosin from human erythrocytes.
Wong AJ,
Kiehart DP, Pollard TD.
J Biol Chem.
1985;
260
(1):
46-9
-
Actin filament stress fibers in vascular endothelial cells in vivo.
Wong AJ,
Pollard TD, Herman IM.
Science.
1983;
219
(4586):
867-9
-
Contractile proteins in endothelial cells.
Herman IM,
Pollard TD, Wong AJ.
Ann N Y Acad Sci.
1982:
401
50-60
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