Publications
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Bridging the transgenerational gap with epigenetic memory.
Lim JP,
Brunet A.
Trends Genet.
2013;
29
(3):
176-86
-
Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.
Rafalski VA,
Ho PP, Brett JO, Ucar D, Dugas JC, Pollina EA, Chow LM, Ibrahim A, Baker SJ, Barres BA, Steinman L, Brunet A.
Nat Cell Biol.
2013;
15
(6):
614-24
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FOXO flips the longevity SWItch.
Webb AE,
Brunet A.
Nat Cell Biol.
2013;
15
(5):
444-6
-
Aging and reprogramming: a two-way street.
Mahmoudi S,
Brunet A.
Curr Opin Cell Biol.
2012;
24
(6):
744-56
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Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis.
Banko MR,
Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A.
Mol Cell.
2011;
44
(6):
878-92
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Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.
Greer EL,
Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y, Brunet A.
Nature.
2011;
479
(7373):
365-71
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Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate.
Rafalski VA,
Mancini E, Brunet A.
J Cell Sci.
2012;
125
(Pt 23):
5597-608
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Histone methylation makes its mark on longevity.
Han S,
Brunet A.
Trends Cell Biol.
2012;
22
(1):
42-9
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Methylation by Set9 modulates FoxO3 stability and transcriptional activity.
Calnan DR,
Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A.
Aging (Albany NY).
2012;
4
(7):
462-79
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[Aging and the control of the insulin-FOXO signaling pathway].
Brunet A,
Med Sci (Paris).
2012;
28
(3):
316-20
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A CRTCal link between energy and life span.
Brunet A,
Cell Metab.
2011;
13
(4):
358-60
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Energy metabolism in adult neural stem cell fate.
Rafalski VA,
Brunet A.
Prog Neurobiol.
2011;
93
(2):
182-203
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Epigenetic regulation of aging stem cells.
Pollina EA,
Brunet A.
Oncogene.
2011;
30
(28):
3105-26
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MicroRNA programs in normal and aberrant stem and progenitor cells.
Arnold CP,
Tan R, Zhou B, Yue SB, Schaffert S, Biggs JR, Doyonnas R, Lo MC, Perry JM, Renault VM, Sacco A, Somervaille T, Viatour P, Brunet A, Cleary ML, Li L, Sage J, Zhang DE, Blau HM, Chen C, Chen CZ.
Genome Res.
2011;
21
(5):
798-810
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The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner.
Maures TJ,
Greer EL, Hauswirth AG, Brunet A.
Aging Cell.
2011;
10
(6):
980-90
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The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation.
Brett JO,
Renault VM, Rafalski VA, Webb AE, Brunet A.
Aging (Albany NY).
2011;
3
(2):
108-24
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The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor.
Renault VM,
Thekkat PU, Hoang KL, White JL, Brady CA, Kenzelmann Broz D, Venturelli OS, Johnson TM, Oskoui PR, Xuan Z, Santo EE, Zhang MQ, Vogel H, Attardi LD, Brunet A.
Oncogene.
2011;
30
(29):
3207-21
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Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging.
Valenzano DR,
Sharp S, Brunet A.
G3 (Bethesda).
2011;
1
(7):
531-8
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Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans.
Greer EL,
Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A.
Nature.
2010;
466
(7304):
383-7
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AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity.
Greer EL,
Banko MR, Brunet A.
Ann N Y Acad Sci.
2009:
1170
688-92
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Cancer: When restriction is good.
Brunet A,
Nature.
2009;
458
(7239):
713-4
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Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans.
Greer EL,
Brunet A.
Aging Cell.
2009;
8
(2):
113-27
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FoxO3 regulates neural stem cell homeostasis.
Renault VM,
Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A.
Cell Stem Cell.
2009;
5
(5):
527-39
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Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri.
Valenzano DR,
Kirschner J, Kamber RA, Zhang E, Weber D, Cellerino A, Englert C, Platzer M, Reichwald K, Brunet A.
Genetics.
2009;
183
(4):
1385-95
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FOXO transcription factors in ageing and cancer.
Greer EL,
Brunet A.
Acta Physiol (Oxf).
2008;
192
(1):
19-28
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FoxO transcription factors in the maintenance of cellular homeostasis during aging.
Salih DA,
Brunet A.
Curr Opin Cell Biol.
2008;
20
(2):
126-36
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Signaling networks in aging.
Greer EL,
Brunet A.
J Cell Sci.
2008;
121
(Pt 4):
407-12
-
The FoxO code.
Calnan DR,
Brunet A.
Oncogene.
2008;
27
(16):
2276-88
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Ageing: from stem to stern.
Brunet A,
Rando TA.
Nature.
2007;
449
(7160):
288-91
-
Aging and cancer: killing two birds with one worm.
Brunet A,
Nat Genet.
2007;
39
(11):
1306-7
-
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
Greer EL,
Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, Gygi SP, Brunet A.
Curr Biol.
2007;
17
(19):
1646-56
-
FOXO transcription factors.
Carter ME,
Brunet A.
Curr Biol.
2007;
17
(4):
R113-4
-
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.
Greer EL,
Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A.
J Biol Chem.
2007;
282
(41):
30107-19
-
FOXO transcription factors at the interface between longevity and tumor suppression.
Greer EL,
Brunet A.
Oncogene.
2005;
24
(50):
7410-25
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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Brunet A,
Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.
Science.
2004;
303
(5666):
2011-5
-
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation.
Chou FL,
Hill JM, Hsieh JC, Pouyssegur J, Brunet A, Glading A, Uberall F, Ramos JW, Werner MH, Ginsberg MH.
J Biol Chem.
2003;
278
(52):
52587-97
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The many forks in FOXO's road.
Tran H,
Brunet A, Griffith EC, Greenberg ME.
Sci STKE.
2003;
2003
(172):
RE5
-
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.
Brunet A,
Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB.
J Cell Biol.
2002;
156
(5):
817-28
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DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein.
Tran H,
Brunet A, Grenier JM, Datta SR, Fornace AJ, DiStefano PS, Chiang LW, Greenberg ME.
Science.
2002;
296
(5567):
530-4
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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).
Brunet A,
Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME.
Mol Cell Biol.
2001;
21
(3):
952-65
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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway.
Brunet A,
Datta SR, Greenberg ME.
Curr Opin Neurobiol.
2001;
11
(3):
297-305
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Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1.
Shin I,
Bakin AV, Rodeck U, Brunet A, Arteaga CL.
Mol Biol Cell.
2001;
12
(11):
3328-39
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Substrate recognition domains within extracellular signal-regulated kinase mediate binding and catalytic activation of mitogen-activated protein kinase phosphatase-3.
Nichols A,
Camps M, Gillieron C, Chabert C, Brunet A, Wilsbacher J, Cobb M, Pouyssegur J, Shaw JP, Arkinstall S.
J Biol Chem.
2000;
275
(32):
24613-21
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
Brunet A,
Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME.
Cell.
1999;
96
(6):
857-68
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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Bonni A,
Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME.
Science.
1999;
286
(5443):
1358-62
-
Cellular survival: a play in three Akts.
Datta SR,
Brunet A, Greenberg ME.
Genes Dev.
1999;
13
(22):
2905-27
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Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.
Brunet A,
Roux D, Lenormand P, Dowd S, Keyse S, Pouysségur J.
EMBO J.
1999;
18
(3):
664-74
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Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins.
Lenormand P,
Brondello JM, Brunet A, Pouysségur J.
J Cell Biol.
1998;
142
(3):
625-33
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Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation.
Englaro W,
Bertolotto C, Buscà R, Brunet A, Pagès G, Ortonne JP, Ballotti R.
J Biol Chem.
1998;
273
(16):
9966-70
-
Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-kappa B and AP-1 transcription factors.
Briant L,
Robert-Hebmann V, Sivan V, Brunet A, Pouysségur J, Devaux C.
J Immunol.
1998;
160
(4):
1875-85
-
[Signal transduction from the membrane to the nucleus: variations on common themes].
Brunet A,
Bull Cancer.
1998;
85
(6):
527-37
-
Mammalian MAP kinase modules: how to transduce specific signals.
Brunet A,
Pouysségur J.
Essays Biochem.
1997:
32
1-16
-
The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade.
Brondello JM,
Brunet A, Pouysségur J, McKenzie FR.
J Biol Chem.
1997;
272
(2):
1368-76
-
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.
Lavoie JN,
L'Allemain G, Brunet A, Müller R, Pouysségur J.
J Biol Chem.
1996;
271
(34):
20608-16
-
Identification of MAP kinase domains by redirecting stress signals into growth factor responses.
Brunet A,
Pouysségur J.
Science.
1996;
272
(5268):
1652-5
-
B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.
Papin C,
Eychène A, Brunet A, Pagès G, Pouysségur J, Calothy G, Barnier JV.
Oncogene.
1995;
10
(8):
1647-51
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The mouse p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1) gene. Genomic organization and structure of the 5'-flanking regulatory region.
Pagès G,
Stanley ER, Le Gall M, Brunet A, Pouysségur J.
J Biol Chem.
1995;
270
(45):
26986-92
-
[MAP kinase module: role in the control of cell proliferation].
Brunet A,
Brondello JM, L'Allemain G, Lenormand P, McKenzie F, Pagès G, Pouysségur J.
C R Seances Soc Biol Fil.
1995;
189
(1):
43-57
-
Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).
Pagès G,
Brunet A, L'Allemain G, Pouysségur J.
EMBO J.
1994;
13
(13):
3003-10
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Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts.
Brunet A,
Pagès G, Pouysségur J.
Oncogene.
1994;
9
(11):
3379-87
-
Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1).
Brunet A,
Pagès G, Pouysségur J.
FEBS Lett.
1994;
346
(2-3):
299-303
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Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts.
Lenormand P,
Sardet C, Pagès G, L'Allemain G, Brunet A, Pouysségur J.
J Cell Biol.
1993;
122
(5):
1079-88
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